The St. Louis Cardinals close out a road series against the Milwaukee Brewers on Sunday, September 27, 2026, with first pitch set for 3:10 PM ET at American Family Field. Andre Pallante takes the ball for St. Louis against Brewers right-hander Jacob Misiorowski in a late-September regular season matchup that carries real weight as both clubs navigate the final stretch of the 2026 schedule. For a Cardinals team looking to finish strong, this is a game that matters on multiple levels.
Cardinals at Brewers: Sunday September 27 Starting Pitchers
Andre Pallante gets the call for St. Louis. The right-hander has been a reliable arm for the Cardinals rotation, valued for his ability to generate weak contact and keep the Cardinals in ball games. Pallante's profile — heavy on ground balls, light on walks when he is on — suits a road environment where keeping the Brewers' lineup from stringing together extra-base hits is the priority.
Milwaukee counters with Jacob Misiorowski, a young pitcher who has drawn attention for his raw stuff. Misiorowski can be electric, but hitters who stay disciplined and work counts have had success against him. The Cardinals' approach at the plate against a power arm like Misiorowski will be a defining factor in how this game unfolds.
Three Keys to Watch for St. Louis
- Pallante's first-inning efficiency: How quickly Pallante works through Milwaukee's order early will set the tone. If he can limit deep counts and get ahead of hitters, St. Louis has a real shot at keeping this close.
- Plate discipline against Misiorowski: Young power pitchers thrive when lineups chase out of the zone. The Cardinals need to trust the process, work counts, and make Misiorowski earn every out. Walks and deep counts will turn this game in St. Louis's favor.
- Bullpen management: With the regular season winding down, how the Cardinals handle their bullpen arms behind Pallante could signal roster-building decisions ahead. Watch who gets high-leverage innings late.
Prediction
This is a classic late-season grind game — two clubs, two pitchers, and a 3:10 ET first pitch that demands the Cardinals bring their best professional at-bats. Pallante is capable of giving St. Louis six quality innings if his defense plays clean behind him. Misiorowski's ceiling is high, but disciplined Cardinals hitters can expose his command early. Expect a tight, low-scoring affair that comes down to one or two big swings. Cardinals pull it out, 3-2.
Catch the game on Cardinals.TV Presented by bet365 or listen live on KMOX 1120 AM/104.1 FM.
