The St. Louis Cardinals dropped a 6-4 decision to the Milwaukee Brewers at American Family Field on Sunday, September 27, 2026, as starter Andre Pallante was tagged for 10 hits and six earned runs across five innings. A Leo Bernal home run accounted for three of the Cardinals' four runs, but Milwaukee's bullpen held the line after Jacob Misiorowski shut down the St. Louis offense through 5.1 innings. The loss hands the Brewers a two-run division victory and keeps the Cardinals on the wrong side of a key NL Central matchup late in the regular season.

Andre Pallante Struggles Against Milwaukee Lineup

Pallante had little margin for error against the Brewers, and he got none. The right-hander was touched up for 10 hits and a walk over five innings, surrendering all six Milwaukee runs before turning the ball over to the bullpen. He struck out four but could not limit the damage, taking the loss in a performance that put St. Louis in a hole it could never fully dig out of.

Jackson Chourio led the Milwaukee attack, going 3-for-4 with two RBI to pace the Brewers' offense. Gary Sánchez added a solo home run and drove in two as Milwaukee spread the damage across multiple hitters rather than relying on one big blow.

Bernal Homer Provides Cardinals' Best Moment

The Cardinals' most productive moment came from Leo Bernal, who hit a home run and drove in three runs on just one hit in two at-bats. His blast gave St. Louis life, but it ultimately wasn't enough against a Milwaukee club that had built its lead on Pallante's early struggles.

The Cardinals managed only four runs total, and outside of Bernal's contribution the offense could not generate consistent pressure against a Brewers pitching staff that locked things down after the fifth inning.

Misiorowski and Milwaukee Bullpen Shut the Door

Jacob Misiorowski was sharp for Milwaukee, going 5.1 innings while allowing just two hits, two walks, and zero earned runs with five strikeouts. He earned the win. When Misiorowski exited, DL Hall followed with 1.2 scoreless innings, striking out one and allowing no hits.

The one rough patch came from Chad Patrick, who allowed four earned runs on two hits and two walks in just one-third of an inning — but by that point Milwaukee had enough of a cushion to survive it. Shane Drohan closed things out with 1.2 scoreless innings, fanning two without issuing a walk, and earned the save.

Justin Bruihl and Hancel Rincon combined to throw three scoreless innings out of the St. Louis bullpen, with Rincon striking out two in a clean final frame — but the Cardinals' relief work came too late to matter.

Key Performances at a Glance

Milwaukee Brewers

  • Jackson Chourio: 3-for-4, 2 RBI
  • Gary Sánchez: 1-for-4, 1 HR, 2 RBI
  • Jacob Misiorowski (W): 5.1 IP, 2 H, 0 ER, 2 BB, 5 K
  • Shane Drohan (SV): 1.2 IP, 0 H, 0 ER, 0 BB, 2 K

St. Louis Cardinals

  • Leo Bernal: 1-for-2, 1 HR, 3 RBI
  • Andre Pallante (L): 5.0 IP, 10 H, 6 ER, 1 BB, 4 K
  • Justin Bruihl: 2.0 IP, 0 H, 0 ER, 0 BB, 0 K
  • Hancel Rincon: 1.0 IP, 0 H, 0 ER, 0 BB, 2 K

What's Next for the Cardinals

St. Louis returns to action following this division setback. The Cardinals will need a bounce-back start from their rotation and more consistent production across the lineup as the regular season winds toward its conclusion. Sunday's result is a reminder that Pallante's outings need to go deeper and with less damage if the Cardinals want to gain ground in the NL Central.